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Prof. Livio Racané, Ph.D.


Department of Applied Chemistry

 Personal data

  • Born: 20. 02. 1969., Rijeka

 Web links

  • http://bib.irb.hr/lista-radova?autor=236842

 Academic education

  • 1997.-Diploma degree in chemistry: Faculty of chemical engineering and technology
  • 2001.-Masters in Natural sciences - Chemistry: Sinthesis of novel supstituted benzothiazoles and bis-benzothiazoles of heterocyclic series, Faculty of chemical engineering and technology, menthor: prof.dr.sc. G. Karminski-Zamola
  • 2005.-PhD thesis - Natural sciences - Chemistry - Organic chemistry: Biologicaly active amidino substituted benzothiazoles, Faculty of chemical engineering and technology, menthor: prof.dr.sc. V. Tralić-Kulenović

 Employment and titles

  • 1997.-2001. young scientist Faculty of Chemical Engineering and Technology, University of Zagreb
  • 2001.-2005. assistant Faculty of Textile Technology University of Zagreb
  • 2005.-2007. senior assistant Faculty of Textile Technology University of Zagreb
  • 2007.-2012. assistant professor Faculty of Textile Technology University of Zagreb
  • 2012.-present associate professor Faculty of Textile Technology University of Zagreb

 Teaching activity

  • Organic Chemistry I
  • Textile Chemistry
  • Polymer Chemistry
  • Chemistry of Dyes
  • Basic Spectroscopic Analysis
  • Organic Chemistry II
  • Spectroscopic Characterization of Dyes and pigments
  • Structure and properties of dyes


Bachelor's degree works:

  • Mario Herceg - Methods of direct arylation of thiophene using metal catalysts: 14. 09. 2020.
  • Magda Relić - Synthesis of new 2,5-substituted furans as potential dyes: 14. 09. 2020.
  • Stefana Begović - Preparation of benzimidazole derivatives as potential optical brighteners: 05. 09. 2019.
  • Marija Mudrešić - Synthesis of novel 6-amidino substituted 2-phenylbenzoxazole: 13. 09. 2017.
  • Marija Čerkez - Preparation of amidino-derivatives as potential cationic dyes: 13. 09. 2017.

  • Nikolina Suhić - Preparation of 5-substituted benzothiazoles: 15. 09. 2017.

  • Katarina Ištef - Optimization of reduction of 4-hydroxy-3-nitrobenzonitrile: 13. 07. 2017.

  • Tea Vujičić - Optimization of the reaction, and isolation of the isomeric nitro-substituted cyanophenoles:  13. 09. 2016.

  • Glorija Fajdetić - Synthesis of benzothiazole in glycerol as a green solvent:  13. 09. 2016.

  • Vedrana Krmpotić - Diazonium salts in the synthesis of azo dyes: 10. 07. 2014.
  • Jelena Peran - Synthesis and characterization of new heteroaromatic multifunctional dyes: 12. 07. 2012.
  • Petra Meštrović - Synthesis of novel azo compounds as potential dyes: 23. 09. 2009.
  • Marija Pavlović - Synthesis and investigation of new disperse dye: 19. 01. 2009.

Final master works:

  • Marija Mudrešić - Green synthesis and characterization of novel amidino-substituted 2-phenylbenzothiazoles as potential multifunctional dyes:  27. 09. 2019.
  • Glorija Fajdetić - Ecologically acceptable synthesis of 5- and 6- substituted 2-phenylbenzothiazole as potential multifunctional dyes: 12. 10. 2018.
  • Vedrana Krmpotić - Synthesis and dyeing properties of new isomeric benzothiazole anionic azo dyes: 28. 09. 2016.
  • Petra Meštrović - Synthesis, characterization and dyeing properties of new azo-naphtosulfonic derivatives of benzothiazoles: 13. 07. 2015.
  • Marija Pavlović - Benzothiazole cyanine dyes: synthesis and spectroscopic characterization: 29. 03. 2011.
  • Ana Trtica - New heterocyclic azo dyes: 01. 02. 2012.

PhD works:

  • Lucija Ptiček - Novel synthetic methods for preparation of Amidino-substituted benzazoles and their Antiproliferative activity - Faculty of Science University of Zagreb: 18. 12. 2020.

Works awarded by Rector of University:

  • Petra Meštrović - Synthesis of novel heterocyclic azo naphthalensulfonic dyes and their application to textiles, awarded: 2013.
  • Vinko Baranašić, Maja Koričić - Dyeing properties of new azoxy compound, awarded: 2005.

 Research activity

  • natural sciences, chemistry, organic chemistry

 Area of special research interest

  • Design, synthesis and spectroscopic characterization (UV/Vis, FT-IR, 1H NMR, 13C NMR, 2D NMR, LC-MS) of new organic heterocyclic compounds and investigation of their biological activity and dyeing properties

 Scientific-professional work

  • 31 Journal articles in WoSCC journals
  • 3 Scientific conference papers with international peer-review
  • 1 Professional conference papers with international peer-review
  • 3 Scientific conference papers with national peer-review
  • 1 Professional conference papers with national peer-review
  • 40 Abstracts in Book of abstracts from national and international scientific conference

 List of key scientific papers:

  • Ptiček, L.; Hok, L.; Grbčić, P.; Topić, F.; Cetina, M.; Rissanen, K.; Pavelić Kraljević, S.; Vianello, R.; Racané, L. Amidino substituted 2-aminophenols: biologically important building blocks for the amidino- functionalization of 2-substituted benzoxazoles. Organic & biomolecular chemistry, 19 (2021), 2784-2793. Q1
  • Racané, L.; Cindrić, M.; Zlatar, I.; Kezele, T.; Milić, A.; Brajša, K.; Hranjec, M. Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles. Journal of enzyme inhibition and medicinal chemistry, 36 (2021), 163-174. Q1
  • Racané, L.; Ptiček, L.; Fajdetić, G.; Tralić-Kulenović, V.; Klobučar, M.; Kraljević Pavelić, S.; Perić, M.; Čipčić Paljetak, H.; Verbanac, D.; Starčević, K. Green synthesis and biological evaluation of 6-substituted-2-(2- hydroxy/methoxyphenyl)benzothiazole derivatives as potential antioxidant, antibacterial and antitumor agents. Bioorganic chemistry, 95 (2020), 103537. Q1
  • Racané, L.; Ptiček, L.; Sedić, M.; Grbčić, P.; Kraljević Pavelić, S.; Bertoša, B.; Sović, I.; Karminski-Zamola, G. Eco-friendly synthesis, in vitro anti- proliferative evaluation and 3D-QSAR analysis of a novel series of monocationic 2- aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates. Molecular diversity, 22 (2018), 723-741. Q2

  • Racané, L.; Sedić, M.; Ilić, N.; Aleksić, M.; Kraljević Pavelić, S.; Karminski-Zamola, G. Novel 2-Thienyl- and 2-Benzothienyl-Substituted 6-(2-Imidazolinyl)Benzothiazoles: Synthesis ; in vitro Evaluation of Antitumor Effects and Assessment of Mitochondrial Toxicity. Anti-Cancer Agents in Medicinal Chemistry, 17 (2017), 57-66. Q2

  • Racané, L.; Stojković, R.; Tralić-Kulenović, V.; Cerić, H.; Đaković, M.; Ester, K.; Mišir Krpan, A.; Radić Stojković, M. Interactions with polynucleotides and antitumor activity of amidino and imidazolinyl substituted 2-phenylbenzothiazole mesylates. European journal of medicinal chemistry, 86 (2014), 406-419. Q1
  • Racané, L.; Kraljević Pavelić, S.; Nhili, R.; Depauw, S.; Paul-Constant, C.; Ratkaj, I.; David-Cordonnier, M-H.; Pavelić, K.; Tralić-Kulenović,V.; Karminski-Zamola, G. New anticancer active and selective phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding. European journal of medicinal chemistry, 63 (2013), 882-891. Q1
  • Racané, L.; Mihalić, Z.; Cerić, H.; Popović, J.; Tralić-Kulenović, V. Synthesis, structure and tautomerism of two benzothiazolyl azo derivatives of 2-naphtol: A crystallographic, NMR and computational study. Dyes and pigments, 96 (2013), 672-678. Q1
  • Racané, L.; Kraljević Pavelić, S.; Ratkaj, I.; Stepanić, V.; Pavelić, K.; Tralić-Kulenović,V.; Karminski-Zamola, G. Synthesis and antiproliferative evaluation of somne new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine. European journal of medicinal chemistry, 55 (2012), 108-116. Q1
  • Racané, L.; Čičak, H; Mihalić, Z.; Karminski-Zamola, G.; Tralić-Kulenović, V. New pentacyclic ring systems: intramolecular cyclization of o,o’-disubstituted bibenzothiazoles. Tetrahedron, 67 (2011), 2760-2767. Q2
  • Racané, L.; Tralić-Kulenović,V.; Kraljević Pavelić, S.; Ratkaj, I.; Peixoto, P.; Nhili, R.; Depauw, S.; Hildebrand, M-P.; David-Cordonnier, M-H.; Pavelić, K.; Karminski-Zamola, G. Novel Diamidino-Substituted Derivatives of Phenyl-Benzothiazolyl- and Dibenzothiazolyl-Furans and Thiophenes: Synthesis, Antiproliferative and DNA binding Properties. Journal of medicinal chemistry, 53 (2010), 2418-2432. Q1
  • Racané, L.; Kralj, M.; Šuman, L.; Stojković, R.; Tralić-Kulenović, V.; Karminski-Zamola, G. Novel amidino substituted 2-phenylbenzothiazoles : Synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo. Bioorganic & medicinal chemistry, 18 (2010), 1038-1044. Q2

  • Pavlović, G.; Racané, L.; Čičak, H.; Tralić-Kulenović, V. The synthesis and structural study of two benzothiazolyl azo dyes. X-ray crystallographic and computational study of azo-hydrazone tautomerism. Dyes and Pigments, 83 (2009), 354-362. Q1

  • Racané, L.; Tralić-Kulenović, V.; Mihalić, Z.; Pavlović, G.; Karminski-Zamola, G. Synthesis of new amidino-substituted 2-aminothiophenoles: mild basic ring opening of benzothiazole.Tetrahedron, 64 (2008), 11594-11602. Q2

 Projects (chief researcher)

  • 2013.-2014. national project: Investigation of New Multifunctional Dyestuffs and Optical Brighteners, (MZOS 117-0000000-3283)
  • 2013.-2014. university scientific support: Benzazole ligands and their metal complexes-new dyes and biologically active compounds (UniZg, –Support 1)

 Projects (collaborator)

  • 2018.- now national project: Exploring the antioxidative potential of benzazole scaffold in the design of novel antitumor agents (HRZZ-IP-2018-01-4379)
  • 2014.- 2018. national project: Synthesis and Cytostatic Evaluations of Novel Nitrogen Heterocycles library (HRZZ-IP-2013-11-5596)
  • 2008.- 2013. national project: Investigation of New Multifunctional Dyestuffs and Optical Brighteners (MZOS 117-0000000-3283)
  • 2007.- 2014. national project: Molecular modeling of structure and reactivity of organic compounds (MZOS 119-1191342-1339)
  • 2002.- 2006. national project: New Heterocyclic Compounds; Synthesis, Anti-infective and Antitumor Activity (MZOS 0125005)
  • 1997.- 2002. national project: Synthesis of Novel Nonnucleozidic Heterocycles for treating HIV (MZOS 125005)
  • 1996.- 1999. international project: Bis-benzothiazolyl amidines aspotential anti-HIV opportunistic diseases agents (MZOS, HR i National institute of Health, Bethesda, USA)

 Acknowledgments and rewards

  • University of Zagreb - 1994.- Rector award
  • University of Zagreb - 1995.- Rector award
  • University of Zagreb Faculty of Textile technology - 2021. Dean award

Prof. Livio Racané, Ph.D.